Jake Neumann, Ph.D.

Jake Neumann, PhD

Jake Neumann, Ph.D.
Vice Chair Biomedical Sciences
Biomedical Sciences

Office: A315
Lab: 217 Science Building
Phone: (304) 793-6236
Fax: (304) 793-6884

Education and Training

Ph.D., Pharmacology, Southern Illinois University School of Medicine

Postdoctoral training, University of Miami Miller School of Medicine

Research Interests

Currently, my lab is studying hippocampal neuronal damage following cerebral ischemia and various mechanism for neuroprotection.

Our interests including understanding how excitatory and inhibitory neurotransmission is altered following ischemia, investigating various methods to improve synaptic signaling for functional recovery, and identifying pharmacological agents for neuroprotection.

Research publications, peer reviewed:

  1. Chen PY, Wu CYC, Clemons GA, Citadin CT, Couto e Silva A, Possoit HE, Azizbayeva R, Forren NE, Liu CH, Rao KNS, Krzywanski DM, Lee RHC, Neumann JT, and Lin HW. Stearic Acid Methyl Ester Affords Neuroprotection and Improves Functional Outcomes after Cardiac Arrest. Prostaglandins Leukot Essent Fatty Acids. Accepted May 2020.
  2. Wu CYC, Lopez-Toledano MA, Daak AA, Clemons GA, Citadin CT, Sancilio FD, Rabinowicz AL, Minagar A, Neumann JT, Lee RHC, Lin HW, SC411 treatment can enhance survival in a mouse model of sickle cell disease. Prostaglandins Leukot Essent Fatty Acids (2020), doi: https://doi.org/10.1016/j.plefa.2020.102110
  3. Lee RHC, Couto e Silva A, Possoit HE, Lerner FM, Chen PY, Azizabayeva R, Citadin CT,  Wu CYC, Neumann JT, and Lin HW. Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest. Prostaglandins Leukot Essent Fatty Acids. 2019 Aug;147:6-14. doi: https://doi.org/10.1016/j.plefa.2018.11.011
  4. Wu CYC, Lerner FM, Couto e Silva A, Neumann JT, Minagar A, Lin HW, and Lee RHC. Utilizing the Modified T-Maze to Assess Functional Memory Outcomes after Cardiac Arrest. J. Vis. Exp. (131), 2018. doi: https://doi.org/10.3791/56694
  5. Lee RHC, Couto e Silva A, Lerner FM, Wilkins CS, Valido SE, Klein DD, Wu CYC, Neumann JT, Della-Morte D, Koslow SH, Minagar A, and Lin HW. Interruption of Perivascular Sympathetic Nerves of Cerebral Arteries Offers Neuroprotection Against Ischemia. Am J Physiol Heart Circ Physiol. 2017 Jan 1;312. doi: https://doi.org/10.1152/ajpheart.00482.2016
  6. Lee RHC, Vasquez JJC, Couto e Silva A, Klein DD, Valido SE, Chen JA, Lerner FM, Neumann JT, Wu CYC, and Lin HW. Fatty acid methyl esters as a potential therapy against cerebral Ischemia. Oilseeds & fats Crops and Lipids. 2015 October 02.
  7. Koronowski KB, Dave KR, Saul I, Camarena V, Thompson JW, Neumann JT, Young JI, Perez-Pinzon MA. Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain. Stroke. 2015 Jul 9.
  8. Cohan CH, Neumann JT, Dave KR, Alekseyenko A, Binkert M, Stransky K, Lin HW, Barnes CA, Wright CB, Perez-Pinzon MA. Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. PLoS One. 2015 May 1;10(5):e0124918. doi: 10.1371/journal.pone.0124918. eCollection 2015. PubMed PMID: 25933411.
  9. Neumann JT, Thompson JW, Raval AP, Cohan CH, Koronowski KB, Perez-Pinzon MA. Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection. J Cereb Blood Flow Metab. 2015 Jan;35(1):121-30. doi: 10.1038/jcbfm.2014.185. Epub 2014 Nov 5. PubMed PMID: 25370861.
  10. Morris-Blanco KC, Cohan CH, Neumann JT, Sick TJ, Perez-Pinzon MA. Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex. J Cereb Blood Flow Metab. 2014 Jun;34(6):1024-32. doi: 10.1038/jcbfm.2014.51. Epub 2014 Mar 26. PubMed PMID: 24667915.
  11. Lin HW, Gresia VL, Stradecki HM, Alekseyenko A, Dezfulian C, Neumann JT, Dave KR, Perez-Pinzon MA. Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. J Cereb Blood Flow Metab. 2014 Apr;34(4):613-20. doi: 10.1038/jcbfm.2013.232. Epub 2014 Jan 22. PubMed PMID: 24447953.
  12. Lin HW, Saul I, Gresia VL, Neumann JT, Dave KR, Perez-Pinzon MA. Fatty acid methyl esters and Solutol HS 15 confer neuroprotection after focal and global cerebral ischemia. Transl Stroke Res. 2014 Feb;5(1):109-17. doi: 10.1007/s12975-013-0276-z. Epub 2013 Aug 6. PubMed PMID: 24323706.
  13. Neumann JT, Cohan CH, Dave KR, Wright CB, Perez-Pinzon MA. Global cerebral ischemia: synaptic and cognitive dysfunction. Curr Drug Targets. 2013 Jan 1;14(1):20-35. Review. PubMed PMID: 23170794.

For a full list of publications visit National Library of Medicine